Hailing from Aix-en-Provence, Pain studied political sciences before moving to Paris to work in a web agency, and then a design agency. Not originally intending to be a singer, a demo she had recorded vocals on for a friend accidentally found its way into the hands of Nouvelle Vague. Subsequently, she has toured for five years with the band.

She sings in both French and English, after years of covering English songs for Nouvelle Vague. Her influences include The Pixies, Sonic Youth, PJ Harvey and Nick Drake.

In April 2009, Pain released her first solo album entitled My Name featuring artists such as Julien Doré, Phoebe Killdeer and Thomas Dybdahl.